식품영양학과 | 교수소개

기본정보

이름

김재한 (Kim Jaehan)

전공

식품미생물학

연락처

042-821-6834

홈페이지

http://nfml.kr/

학력

● 박사 : University of California, Davis, Department of Food Science & Technology, 식품미생물학 전공 (2004-12-30)
[졸업논문] Simultaneous utilization of mixed carbohydrates by lactobacilli: Physiology aspects and application on bio-based chemical production
● 석사 : 서울대학교  식품공학과 생물화학공학 전공 (1999-02-28)
[졸업논문] Optimization of Xylitol Production by Xylose bioconversion using Candida tropicalis ATCC 13803
● 학사 : 서울대학교 식품공학과 식품공학 전공

경력

● 충남대학교 / 교수/ 책임급 (2020-03 ~ 현재)
● 충남대학교 / 학장 (2017-02 ~ 2019-02)
● 충남대학교 / 부교수 (2015-03 ~ 2019-02)
● 충남대학교 / 부학장 (2014-07 ~ 2016-07)
● 충남대학교 / 학과장 (2014-06 ~ 2016-07)
● 충남대학교 / 조교수 (2011-02 ~ 2015-02)
● Robert Mondavi Institute for Wine and Food Science / staff research associate (2010-01 ~ 2011-02)
● University of California, Davis / 전임강사 (2007-03 ~ 2007-07)
● University of California, Davis / POST-DOC (2005-01 ~ 2009-12)
● 청강문화산업대학 / 시간강사 (1998-08 ~ 1999-08)
● 서울대학교 / 연구원 (1998-03 ~ 1999-07)

논문

[2021]
● Kim, J. E., Tran, P. L., Ko, J. M., Kim, S. R., Kim, J. H., and Park, J. T. (2021) Comparison of catalyzing properties of bacterial 4-a-glucanotransferases focusing on their cyclizing activity. J Microbiol Biotechnol 31, 41-50

[2020]
● Won, S., Lee, J., Kim, J., and Choi, H. (2020) Comparative Whole Cell Proteomics of Listeria monocytogenes at Different Growth Temperatures. J Microbiol Biotechnol 30, 259-270
● Nguyen, M. T. T., Kim, J., Lee, H., Won, S., Kim, Y., Jung, J. A., Li, D., To, X. H. M., Huynh, K. T. N., Le, T. V., Israr, B., An, H. J., and Kim, J. (2020) A Comparison of Vitamin and Lutein Concentrations in Breast Milk from Four Asian Countries. Nutrients 12
● Lee, J., Ha, S., Kim, M., Kim, S. W., Yun, J., Ozcan, S., Hwang, H., Ji, I. J., Yin, D., Webster, M. J., Shannon Weickert, C., Kim, J. H., Yoo, J. S., Grimm, R., Bahn, S., Shin, H. S., and An, H. J. (2020) Spatial and temporal diversity of glycome expression in mammalian brain. Proc Natl Acad Sci U S A 117, 28743-28753
● Lee, H., Lee, A., Seo, N., Oh, J., Kweon, O. K., An, H. J., and Kim, J. (2020) Discovery of N-glycan Biomarkers for the Canine Osteoarthritis. Life (Basel) 10
● Jeong, S., Oh, M. J., Kim, U., Lee, J., Kim, J. H., and An, H. J. (2020) Glycosylation of serum haptoglobin as a marker of gastric cancer: an overview for clinicians. Expert Rev Proteomics 17, 109-117
● 윤효원, 이아현, 김지은, and 김재한. (2020) Bifidobacterium sp. 고농도 성장을 위한 환경인자 및 세포활성도 최적화. KSBB 35, 34-43

[2019]
● Yeo, I. S., Yoon, Y. J., Seo, N., An, H. J., and Kim, J. H. (2019) Biopurification of Oligosaccharides by Immobilized Kluyveromyces Lactis. Appl Sci-Basel 9, 2845
● Nguyen, P. C., Nguyen, M. T. T., Lee, C.-K., Oh, I.-N., Kim, J.-H., Hong, S.-T., and Park, J.-T. (2019) Enzymatic synthesis and characterization of maltoheptaose-based sugar esters. Carbohydrate Polymers 218, 126-135
● Hahn, W. H., Kim, J., Song, S., Park, S., and Kang, N. M. (2019) The human milk oligosaccharides are not affected by pasteurization and freeze-drying. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet 32, 985-991

[2018]
● Park, Y.-U., Jung, J.-H., Seo, D.-H., Jung, D.-H., Kim, J.-H., Seo, E.-J., Baek, N.-I., and Park, C.-S. (2018) GH57 amylopullulanase from Desulfurococcus amylolyticus JCM 9188 can make highly branched cyclodextrin via its transglycosylation activity. Enzyme Microb Technol 114, 15-21
● Lee, J., Hua, S., Lee, S. H., Oh, M. J., Yun, J., Kim, J. Y., Kim, J.-H., Kim, J. H., and An, H. J. (2018) Designation of fingerprint glycopeptides for targeted glycoproteomic analysis of serum haptoglobin: insights into gastric cancer biomarker discovery. Analytical and bioanalytical chemistry 410, 1617-1629
● 윤여진, 이아현, 박종태, 윤상만, and 김재한. (2018) 쿼세틴 복합체의 생물학적 이용성 향상을 위한 양파 추출물의 유산균 발효. 한국식품과학회지 50, 391-399

[2017]
● Nguyen, T. T., Chon, T.-S., Kim, J., Seo, Y.-S., and Heo, M. (2017) Comparative and bioinformatics analyses of pathogenic bacterial secretomes identified by mass spectrometry in Burkholderia species. Journal of Microbiology 55, 568-582
● Kim, M., Jin, Y., An, H.-J., and Kim, J. (2017) Impact of High-Level Expression of Heterologous Protein on Lactococcus lactis Host. J Microbiol Biotechnol 27, 1345-1358
● Kim, J. H., Yun, E. J., Seo, N., Yu, S., Kim, D. H., Cho, K. M., An, H. J., Kim, J.-H., Choi, I.-G., and Kim, K. H. (2017) Enzymatic liquefaction of agarose above the sol-gel transition temperature using a thermostable endo-type beta-agarase, Aga16B. Appl Microbiol Biotechnol 101, 1111-1120
● Kim, J.-H., Lee, S. H., Choi, S., Kim, U., Yeo, I. S., Kim, S. H., Oh, M. J., Moon, H., Lee, J., Jeong, S., Choi, M. G., Lee, J. H., Sohn, T. S., Bae, J. M., Kim, S., Min, Y. W., Lee, H., Lee, J. H., Rhee, P.-L., Kim, J. J., Lee, S. J., Kim, S. T., Lee, J., Park, S. H., Park, J. O., Park, Y. S., Lim, H. Y., Kang, W. K., An, H. J., and Kim, J. H. (2017) Direct analysis of aberrant glycosylation on haptoglobin in patients with gastric cancer. Oncotarget 8, 11094-11104
● Kim, I. J., Seo, N., An, H. J., Kim, J.-H., Harris, P. V., and Kim, K. H. (2017) Type-dependent action modes of TtAA9E and TaAA9A acting on cellulose and differently pretreated lignocellulosic substrates. Biotechnology for biofuels 10, 46
● Chin, Y. W., Kim, J. Y., Kim, J. H., Jung, S. M., and Seo, J. H. (2017) Improved production of 2'-fucosyllactose in engineered Escherichia coli by expressing putative alpha-1,2-fucosyltransferase, WcfB from Bacteroides fragilis. Journal of biotechnology 257, 192-198

[2016]
● Wang, D., Yun, E. J., Kim, S., Kim, D. H., Seo, N., An, H. J., Kim, J.-H., Cheong, N. Y., and Kim, K. H. (2016) Efficacy of acidic pretreatment for the saccharification and fermentation of alginate from brown macroalgae. Bioprocess Biosyst Eng 39, 959-966
● Wang, D., Kim, D. H., Seo, N., Yun, E. J., An, H. J., Kim, J.-H., and Kim, K. H. (2016) A novel glycoside hydrolase family 5 β-1, 3-1, 6-endoglucanase from Saccharophagus degradans 2-40T and its transglycosylase activity. Applied and environmental microbiology, AEM. 00635-00616
● Park, G. W., Kim, J. Y., Hwang, H., Lee, J. Y., Ahn, Y. H., Lee, H. K., Ji, E. S., Kim, K. H., Jeong, H. K., Yun, K. N., Kim, Y.-S., Ko, J.-H., An, H. J., Kim, J. H., Paik, Y.-K., and Yoo, J. S. (2016) Integrated GlycoProteome Analyzer (I-GPA) for Automated Identification and Quantitation of Site-Specific N-Glycosylation. Sci Rep 6, 21175
● Oh, M. J., Hua, S., Kim, U., Kim, H. J., Lee, J., Kim, J.-H., and An, H. J. (2016) Analytical detection and characterization of biopharmaceutical glycosylation by MS. Bioanalysis 8, 711-727
● Lee, S. H., Jeong, S., Lee, J., Yeo, I. S., Oh, M. J., Kim, U., Kim, S., Kim, S. H., Park, S.-Y., Kim, J.-H., Park, S. H., Kim, J. H., and An, H. J. (2016) Glycomic profiling of targeted serum haptoglobin for gastric cancer using nano LC/MS and LC/MS/MS. Mol Biosyst 12, 3611-3621
● Jeong, K. H., Israr, B., Shoemaker, S. P., Mills, D. A., and Kim, J. (2016) Impact of Lactic Acid and Hydrogen Ion on the Simultaneous Fermentation of Glucose and Xylose by the Carbon Catabolite Derepressed Lactobacillus brevis ATCC 14869. J Microbiol Biotechnol 26, 1182-1189
● Chin, Y.-W., Seo, N., Kim, J.-H., and Seo, J.-H. (2016) Metabolic engineering of Escherichia coli to produce 2'-fucosyllactose via salvage pathway of guanosine 5'-diphosphate (GDP)-l-fucose. Biotechnol Bioeng 113, 2443-2452

[2015~2011]
● Kim, S. R., Nguyen, T. V., Seo, N. R., Jung, S., An, H. J., Mills, D. A., and Kim, J. H. (2015) Comparative proteomics: assessment of biological variability and dataset comparability. BMC Bioinformatics 16, 121
● Ozcan, S., Kim, B. J., Ro, G., Kim, J.-H., Bereuter, T. L., Reiter, C., Dimapasoc, L., Garrido, D., Mills, D. A., Grimm, R., Lebrilla, C. B., and An, H. J. (2014) Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. Sci Rep 4, 4963
● Ozcan, S., Barkauskas, D. A., Renee Ruhaak, L., Torres, J., Cooke, C. L., An, H. J., Hua, S., Williams, C. C., Dimapasoc, L. M., Han Kim, J., Camorlinga-Ponce, M., Rocke, D., Lebrilla, C. B., and Solnick, J. V. (2014) Serum glycan signatures of gastric cancer. Cancer Prev Res (Phila) 7, 226-235
● Lee, C. H., Kim, H. T., Yun, E. J., Lee, A. R., Kim, S. R., Kim, J.-H., Choi, I.-G., and Kim, K. H. (2014) A novel agarolytic β-galactosidase acts on agarooligosaccharides for complete hydrolysis of agarose into monomers. Applied and environmental microbiology 80, 5965-5973
● Kim, S.-R., Kim, Y.-M., Jeon, S.-J., Park, J.-T., and Kim, J.-H. (2014) Analysis of carotenoids and soluble sugars in the Rainbow carrots. Korean Journal of Agricultural Science 41, 107-112
● Kim, N.-H., Jung, S.-H., Kim, J., Kim, S.-H., Ahn, H.-J., and Song, K. B. (2014) Purification of an Iron-Chelating Peptide from Spirulina Protein Hydrolysates. Journal of the Korean Society for Applied Biological Chemistry 57, 91-95
● Kim, J.-H., Park, C., Um, D., Baek, K. H., Jo, Y., An, H., Kim, Y., and Kim, T. J. (2014) Mass spectrometric screening of ovarian cancer with serum glycans. Dis Markers 2014, 634289/634289 pages
● Hua, S., Saunders, M., Dimapasoc, L. M., Jeong, S. H., Kim, B. J., Kim, S., So, M., Lee, K.-S., Kim, J. H., Lam, K. S., Lebrilla, C. B., and An, H. J. (2014) Differentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling. J Proteome Res 13, 961−968
● Ozcan, S., An, H. J., Vieira, A. C., Park, G., Kim, J. H., Mannis, M. J., and Lebrilla, C. B. (2013) Characterization of novel O-glycans isolated from tear and saliva of ocular rosacea patients. J Proteome Res 12, 1090–1100
● Kim, J.-H., An, H. J., Garrido, D., German, J. B., Lebrilla, C. B., and Mills, D. A. (2013) Proteomic analysis of Bifidobacterium longum subsp. infantis reveals the metabolic insight on consumption of prebiotics and host glycans. PLoS One 8, e57535
● FAoki-Kinoshita, K., Sawaki, H., An, H. J., Campbell, M., Cao, Q., Cummings, R., KHsu, D., Kato, M., Kawasaki, T., Khoo, K.-H., Kim, J., Kolarich, D., Li, X., Liu, M., Matsubara, M., Okuda, S., HPacker, N., Ranzinger, R., Shen, H., Shikanai, T., Shinmachi, D., Toukach, P., Yamada, I., Yamaguchi, Y., Yang, P., Ying, W., Yoo, J. S., Zhang, Y., Zhang, Y., and Narimatsu, H. (2013) The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository. Glycobiology 23, 1422–1424
● Aoki-Kinoshita, K. F., Sawaki, H., An, H. J., Cho, J. W., Hsu, D., Kato, M., Kawano, S., Kawasaki, T., Khoo, K.-H., Kim, J., Kim, J.-D., Li, X., Lütteke, T., Okuda, S., Packer, N. H., Paulson, J. C., Raman, R., Ranzinger, R., Shen, H., Shikanai, T., Yamada, I., Yang, P., Yamaguchi, Y., Ying, W., Yoo, J. S., Zhang, Y., and Narimatsu, H. (2013) The Year of Glycosciences. Glycobiology 23, 143–146
● VIEIRA, A. C., AN, H. J., OZCAN, S., KIM, J.-H., LEBRILLA, C. B., and MANNIS, M. J. (2012) Glycomic analysis of tear and saliva in ocular rosacea patients: the search for a biomarker. The Ocular Surface 10, 184-192
● Strum, J. S., Kim, J., Wu, S., Leoz, M. L. A. D., Peacock, K., Grimm, R., German, B., Mills, D. A., and Lebrilla, C. B. (2012) Identification and accurate quantitation of biological oligosaccharide mixtures. Anal Chem 84, 7793−7801
● Jeong, K., Nguyen, V., and Kim, J. (2012) Human milk oligosaccharides: the novel modulator of intestinal microbiota. BMB Rep 45, 433-441
● Han, N. S., Kim, T.-J., Park, Y.-C., Kim, J., and Seo, J.-H. (2012) Biotechnological production of human milk oligosaccharides. Biotechnol Adv 30, 1268–1278
● An, H. J., Gip, P., Kim, J., Wu, S., Park, K. W., McVaugh, C. T., Schaffer, D. V., Bertozzi, C. R., and Lebrilla, C. B. (2012) Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Mol Cell Proteomics 11, 1–13
● Tao, N., Wu, S., Kim, J., An, H. J., Hinde, K., Power, M. L., Gagneux, P., German, J. B., and Lebrilla, C. B. (2011) Evolutionary glycomics: characterization of milk oligosaccharides in primates. J Proteome Res 10, 1548–1557
● Garrido, D., Kim, J. H., German, J. B., Raybould, H. E., and Mills, D. A. (2011) Oligosaccharide binding proteins from Bifidobacterium longum subsp. infantis reveal a preference for host glycans. PLoS One 6, e17315
● de Leoz, M. L. A., Young, L. J. T., An, H. J., Kronewitter, S. R., Kim, J., Miyamoto, S., Borowsky, A. D., Chew, H. K., and Lebrilla, C. B. (2011) High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics 10, 1–9
[2010~1996]
● Turroni, F., Bottacini, F., Foroni, E., Mulder, I., Kim, J.-H., Zomer, A., Sanchez, B., Bidossi, A., Ferrarini, A., Giubellini, V., Delledonne, M., Henrissat, B., Coutinho, P., Oggioni, M., Fitzgerald, G. F., Mills, D., Margolles, A., Kelly, D., van Sinderen, D., and Ventura, M. (2010) Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci U S A 107, 19514-19519
● Kim, J.-H., Block, D. E., Shoemaker, S. P., and Mills, D. A. (2010) Conversion of rice straw to bio-based chemicals: an integrated process using Lactobacillus brevis. Applied Microbiology and Biotechnology 86, 1375-1385
● Kim, J.-H., Block, D. E., Shoemaker, S. P., and Mills, D. A. (2010) Atypical ethanol production by carbon catabolite derepressed lactobacilli. Bioresour Technol 101, 8790-8797
● Kim, J.-H., Block, D. E., and Mills, D. A. (2010) Simultaneous consumption of pentose and hexose sugars: an optimal microbial phenotype for efficient fermentation of lignocellulosic biomass. Appl Microbiol Biotechnol 88, 1077-1085
● Kim, J.-H., Shoemaker, S. P., and Mills, D. A. (2009) Relaxed control of sugar utilization in Lactobacillus brevis. Microbiology (Reading) 155, 1351-1359
● Cooke, C. L., An, H. J., Kim, J., Canfield, D. R., Torres, J., Lebrilla, C. B., and Solnick, J. V. (2009) Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology 137, 1061-1071, 1071 e1061-1068
● Sela, D. A., Chapman, J., Adeuya, A., Kim, J. H., Chen, F., Whitehead, T. R., Lapidus, A., Rokhsar, D. S., Lebrilla, C. B., German, J. B., Price, N. P., Richardson, P. M., and Mills, D. A. (2008) The genome sequence of Bifidobacterium longum subsp infantis reveals adaptations for milk utilization within the infant microbiome. P Natl Acad Sci USA 105, 18964-18969
● de Leoz, M. L., An, H. J., Kronewitter, S., Kim, J., Beecroft, S., Vinall, R., Miyamoto, S., de Vere White, R., Lam, K. S., and Lebrilla, C. (2008) Glycomic approach for potential biomarkers on prostate cancer: profiling of N-linked glycans in human sera and pRNS cell lines. Dis Markers 25, 243-258
● Kim, J.-H., and Mills, D. A. (2007) Improvement of a nisin-inducible expression vector for use in lactic acid bacteria. Plasmid 58, 275-283
● Cooke, C. L., An, H. J., Kim, J., Solnick, J. V., and Lebrilla, C. B. (2007) Method for profiling mucin oligosaccharides from gastric biopsies of rhesus monkeys with and without Helicobacter pylori infection. Analytical Chemistry 79, 8090-8097
● Moon, K., Lee, W., Kim, J., Choi, J., Ryu, Y., and Seo, J. (2002) Biological production of xylitol by Candida tropicalis and recombinant Saccharomyces cerevisiae containing xylose reductase gene. Biological Systems Engineering 830, 53-68
● Kim, J. H., Han, K. C., Koh, Y. H., Ryu, Y. W., and Seo, J. H. (2002) Optimization of fed-batch fermentation for xylitol production by Candida tropicalis. J Ind Microbiol Biotechnol 29, 16-19
● Kim, J. H., Ryu, Y. W., and Seo, J. H. (1999) Analysis and optimization of a two-substrate fermentation for xylitol production using Candida tropicalis. J Ind Microbiol Biot 22, 181-186
● Jae-Han Kim, Ryu, Y.-W., and Seo, J.-H. (1997) Effect of environmental factors on xylitol production by Candida tropicalis ATCC 13803. Kor. J. Biotechnol. Bioeng 12, 509-514

특허

●  [대한민국 특허] N-당사슬 크로마토그램 피크의 상대정량에 의한 질병 스크리닝 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1021001580000 (2020-04-07)

●  [대한민국 특허] N-당사슬 이성질체의 상대정량을 이용한 질병 스크리닝 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1020916360000 (2020-03-16)

●  [대한민국 특허] 고정화 클루이베로마이세스 락티스의 락토오스 제거능을 이용한 모유 올리고당의 분리 및 정제방법, 충남대학교산학협력단, 등록번호 : 1020277900000 (2019-09-26)

●  [미국 특허] Diagnostic method for gastric cancer, 등록인 : 한국과학기술원(KASIT), 등록번호 : 10,393,747 (2019-08-27)

●  [대한민국 특허] 인간 타액을 확인하는 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1018641610000 (2018-05-29)

●  [대한민국 특허] 당단백질의 전분자량 측정을 통한 당사슬 모니터링에 의한 암 진단마커 분석방법, 충남대학교산학협력단, 등록번호 : 1018256470000 (2018-01-30)

●  [대한민국 특허] 당단백질의 부위-특이적 당펩타이드 생성 및 분석방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1017547520000 (2017-06-30)

●  [대한민국 특허] N-당사슬 바이오마커를 이용하여 난소암을 탐지하는 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1017485880000 (2017-06-13)

●  [대한민국 특허] 당단백질 분자량 측정을 이용한 실시간 당쇄화 모니터링 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1017439690000 (2017-05-31)

●  [대한민국 특허] 당단백질 분자량 측정을 이용한 실시간 당쇄화 모니터링 방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1017439690000 (2017-05-31)

●  [대한민국 특허] 당단백질의 부위-특이적 O-당펩타이드 생성 및 분석방법, 등록인 : 충남대학교산학협력단, 등록번호 : 1017348630000(2017-05-04)

●  [대한민국 특허] Ｎ-당쇄화된 당펩타이드를 이용한 위암 진단용 마커 조성물, 등록인 : 충남대학교산학협력단, 등록번호 : 1015302100000(2015-06-15)

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